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QTL data sets > Beamer_2001
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| | Bone mineral density and IGF-1 levels in F2 progeny from a C57BL/6J x C3H/HeJ intercross
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| | Beamer_2001
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An intercross of C3H/HeJ and C57BL/6J was generated to identify quantitative trait loci for serum insulin-like growth factor-1 (IGF-1) levels and bone-related phenotypes. F2 females were tested for IGF-1 and analyzed for femur bone mineral density (BMD), strength, and geometry. For detailed protocols see Beamer et al 2001 and Rosen et al 2000.
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Downloads |
Initial release: Jan 2008 see the readme file for details.
| Recent change: 02 Nov 2011 ... | Updated map to build 37 sex-averaged cM; change the name of the map (from 'Shifman' to 'Cox' map) in description file; add QC report PDF file and please see readme file for details. |
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| Reference |
Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206.
MGI
Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Ackert C, Beamer WG. Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. Bone. 2000 Oct;27(4):521-8.
MGI
Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Müller R, Beamer WG. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res. 2004 Apr;19(4):587-99. Epub 2003 Dec 22.
MGI
Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20.
FullText
MGI
Other QTL Archive data sets that are also associated with above publication(s):
Beamer_1999
Ishimori_2004
Wergedal_2006
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| Acknowledgements |
Funding provided by NIH AR43618, AR45433, CA34196; and the U.S. Army (DAMD17-96-1-6306)
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| Progenitor strains |
C57BL/6J
C3H/HeJ
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F2 intercross
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Direction:
(B6xC3H) F1 x (B6xC3H) F1
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| Population |
 N=999
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Age at testing: 16 wks.
Diet for all measurements was Autoclaved NIH-31 (6% fat, 18% protein, Ca:P 1:1, vitamin and mineral fortified); PMI Richmond, IN.
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| body weight size and growth – body weight
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| bone – mineral density and content
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femur_cort_BMD femur, cortical shell volumetric bone mineral density
[mg/mm3]
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femur_tot_BMD femur, total bone mineral density
[mg/mm3]
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femur_tot_vBMD femur, total volumetric bone mineral density
[g/cm3]
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| bone – morphology
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femur_mid_tot_vol femur, average bone volume (total, mid-diaphysis)
[g/cm3]
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femur_mid_cort_vol femur, average cortical bone volume (mid-diaphysis)
[g/cm3]
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femur_pct_cort femur, percent of total volume that is cortical bone
[%]
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femur_ratio femur, surface area to tissue volume (index)
[ratio]
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femur_length femur, length (condyles to rostral tip of greater trochanter)
[mm]
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femur_thickness femur, average cortical thickness (mid-diaphysis)
[mm]
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femur_ML femur, medial to lateral width (mid-diaphysis)
[mm]
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femur_AP femur, anterior to posterior (rostral to caudal) width (mid-diaphysis)
[mm]
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femur_ML_AP femur, ratio of medial-lateral (ML) to anterior-posterior (AP)
[ratio]
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trab_ratio trabecular bone, surface area to volume (ratio)
[ratio]
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trab_thickness trabecular bone, average thickness
[mm]
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trab_number trabecular bone, average number
[n]
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trab_spacing trabecular bone, average spacing
[mm]
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| bone – strength
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femur_load femur, ultimate load
[Ng/mL]
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femur_energy femur, energy to failure
[N⋅mm]
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femur_stiffness femur, stiffness
[N⋅mm]
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femur_inertia femur, cross-sectional moment of inertia
[mm4]
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femur_stress femur, ultimate stress
[N]
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femur_tough femur, elastic modulus (toughness)
[N/mm2]
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femur_break femur, load at specimen failure (break point)
[N]
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| endocrine – hormones
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IGF1_adj insulin-like growth factor 1 (serum IGF-1), normalized
[ng/mL]
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